Comparison of the antibacterial activities of different brands of Ciprofloxacin | Comparación de la actividad antibacterial de diferentes marcas de Ciprofloxacina

Resumen

The present study was carried out to evaluate and compare the antibacterial susceptibility of Gram-positive and Gramnegative bacteria to Cyrocin (Ciprofloxacin). The following three bacterial strains were used: Staphyloccocus aureus [ATCC 25923], Escherichia coli [ATCC 25922] and Pseudomonas aeruginosae [ATCC 27853]. Standard commercial discs of definite potency are used as reference standard (Ciprofloxacin 5g [CTO425B - OXOID Ltd. UK]). The test products were 250 mg and 500 mg tablets of the following brands: Cyrocin (Highnoon Laboratories Limited), Ciproxin (Bayer Pharma (Pvt) Ltd. – Pakistan), Mercip (Merck Marker (Pvt.) Ltd., Pakistan) and Axcin (Sandoz - Norvatis Pharma Ltd., Pakistan). The media used were: Nutrient Broth (Cat. No. 1.05443, Merck, Germany) and Mueller Hinton Agar [Oxoid]. The study showed no statistically significant difference in the results of different brands.
Kew words: Antibacterial properties, Staphyloccocus aureus, Escherichia coli, Pseudomonas aeruginosae, Ciprofloxacin

RESUMEN
El presente estudio se realizó para evaluar y comparar la susceptibilidad antibacterial de las bacterias Gram-positiva y Gram-negativa al Cyrocin (Ciprofloxacina). Se usaron las cepas bacetriales Staphyloccocus aureus [ATCC 25923], Escherichia coli [ATCC 25922] y Pseudomonas aeruginosae [ATCC 27853]. Se utilizaron discos comerciales estandars de potencia definida como estandar de referencia (Ciprofloxacin 5g [CTO425B - OXOID Ltd. UK]). Los productos evaluadoes fueron tabletas de 250 mg y 500 mg de las siguientes marcas: Cyrocin (Highnoon Laboratories Limited), Ciproxin (Bayer Pharma (Pvt) Ltd. – Pakistan), Mercip (Merck Marker (Pvt.) Ltd., Pakistan) y Axcin (Sandoz - Norvatis Pharma Ltd., Pakistan). Los medios usados fueron: Nutrient Broth (Cat. No. 1.05443, Merck, Germany) and Mueller Hinton Agar [Oxoid]. El estudio mostró diferencias estadísticamente no significativas en los resultados de las diferentes marcas,
Palabras clave: Propiedades antibacteriales, Staphyloccocus aureus, Escherichia coli, Pseudomonas aeruginosae,
Ciprofloxacina